Concussion in rats causes an immediate change in occupancy but not affinity of hypothalamic cholinergic receptors
Identifieur interne : 005135 ( Main/Exploration ); précédent : 005134; suivant : 005136Concussion in rats causes an immediate change in occupancy but not affinity of hypothalamic cholinergic receptors
Auteurs : K. R. Shah [Canada] ; V. Havlicek [Canada] ; M. West [Canada] ; F. S. Labella [Canada]Source :
- Brain Research [ 0006-8993 ] ; 1982.
English descriptors
Abstract
Experimental concussion in rats is associated with subsequent enhanced binding in vitro of certain ligands to hypothalamic tissue but not to other brain regions. Scatchard analysis shows that the number of specific binding sites for [3H]quinuclidinylbenzilate increases within 3 s after concussion with no significant change in binding affinity. The apparent increase in receptors is likely the result of a deficit in binding of endogenous ligand. We propose that concussion produces a pressure wave that deforms cholinergic and possibly other receptors selectively in the hypothalamus, resulting in a transient deficit in transmitter binding and interruption of neuronal circuits concerned with the state of consciousness.
Url:
DOI: 10.1016/0006-8993(82)91216-1
Affiliations:
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R." last="Shah">K. R. Shah</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Departments of Physiology and Pharmacology, University of Manitoba, Winnipeg, Manitoba R3E OW3</wicri:regionArea><orgName type="university">Université du Manitoba</orgName><placeName><settlement type="city">Winnipeg</settlement><region type="state">Manitoba</region></placeName></affiliation></author><author><name sortKey="Havlicek, V" sort="Havlicek, V" uniqKey="Havlicek V" first="V." last="Havlicek">V. 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Scatchard analysis shows that the number of specific binding sites for [3H]quinuclidinylbenzilate increases within 3 s after concussion with no significant change in binding affinity. The apparent increase in receptors is likely the result of a deficit in binding of endogenous ligand. We propose that concussion produces a pressure wave that deforms cholinergic and possibly other receptors selectively in the hypothalamus, resulting in a transient deficit in transmitter binding and interruption of neuronal circuits concerned with the state of consciousness.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Manitoba</li></region><settlement><li>Winnipeg</li></settlement><orgName><li>Université du Manitoba</li></orgName></list><tree><country name="Canada"><region name="Manitoba"><name sortKey="Shah, K R" sort="Shah, K R" uniqKey="Shah K" first="K. R." last="Shah">K. R. 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